A Case of Apocrine Adenocarcinoma associated with Basal Cell Carcinoma / 대한피부과학회지

Apocrine adenocarcinoma is rarely reported in the world and only 4 cases are reported in Korean literature. We encountered a case of apocrine adenocarcinoma associated with basal cell carcinoma in a 76-year-old female. Excisional biopsy showed well demarcated basophilic cell mass in the upper dermis and glandular structure in the lower dermis. Basophilic cell mass consisted with basaloid cells and had peripheral palisading arrangement. Glandular structures characterized by cells with abundant eosinophilic cytoplasm showed decapitation secretion. The cells showed nuclear atypicality, plemorphism and prominent nucleoli. The cytoplasm contained PAS-positive, diastase-resistant granules and stains for lysozyme and GCDFP-15(Gross Cystic Disease Fluid Protein-15) were positive.

Comparison of Compliance and Cure Rate of Systemic Antifungal Therapy vs. Combination Therapy with Systemic and Topical Agent in Toenail Onychomycosis / 대한의진균학회지

BACKGROUND: Treatment of toenail onychomycosis requires long term oral medication of antifungal agent and its compliance was about 30% in outpatient base. OBJECTIVE: The objective of this study was to evaluate the efficacy and compliance of combined treatment with systemic and topical antifungal agent in toenail onychomycosis. METHOD: Medical records of 402 patients with toenail onychomycosis were analysed. They were diagnosed by positivity in KOH or fungus culture. Two hundred forty patients took systemic antifungal agent (terbinafine or itraconazole) only (oral treatment group). One hundred sixty two patients took combined treatment with systemic antifungal agent and topical antifungal agent (ciclopirox 8% nail lacquer) (combined treatment group). Compliance, complete cure rate, revisiting rate and follow up period were compared between oral treatment group and combined treatment group. RESULTS: Completely treated rate was higher in combined treatment group (48.2%, 78 out of 162) than in oral treatment group (20.8%, 50 out of 240) (p=0.000, c2). Complete cure rate after complete treatment was higher in combined treatment group (34.6%, 43 out of 78) than in oral treatment group (22.0%, 11 out of 50) (p=0.127, c2). Revisiting rate after complete treatment was higher in combined treatment group (60.5%, 43 out of 71) than in oral treatment group (22.2%, 10 out of 45) (p=0.000, c2). CONCLUSION: All these findings suggested that combined treatment with systemic and topical agent in toenail onychomycosis can increase compliance and cure rate.

Pigmented Spindle Cell Nevus in an Infant / 대한피부과학회지

Pigmented spindle cell nevus (PSCN) was first described by Reed et al. in 1975 as a distinctive form of nevocellular nevus. Although some authors consider PSCN to be a pigmented variant of Spitz nevus, most classify it as a separate disease. We encountered a two year old boy with deeply pigmented macule on the left foot dorsum. It's histologic features were sharply demarcated lateral margin, confinement above reticular dermis and entirely composed of heavily pigmented spindle cells. There were no atypical mitotic fugures or nuclear pleomorphism, and cell size was uniform. The pathologic features were consistent with PSCN.